Lung cancer is the most common cancer in the world and smoking is the major risk factor, accounting for about 90% of the cases. In 1996, an estimated 1.3 million new cases were diagnosed worldwide, accounting for 12.8% of all new cases of cancer (World Cancer Research Fund 1997). Prevention and early detection are the main tools to reduce lung cancer morbidity. In human lung adenocarcinomas, the c-raf and c-myc proto-oncogenes are frequently overexpressed. Two transgenic mouse models were developed to further our knowledge on the specific roles of these proto-oncogenes. The transgenes were targeted to alveolar type II cells through utilization of the surfactant protein C promoter. We are currently determining transcript profiles in lung tum...
Lung squamous cell carcinoma (SCC) is thought to arise from premalignant lesions in the airway epith...
BACKGROUND:Lung cancer is a leading cause of cancer morbidity. To improve an understanding of molecu...
Lung cancer has the highest mortality rate amongst all diagnosed malignancies with adenocarcinoma (A...
During the last decade, high-throughput technologies including genomic, epigenomic, transcriptomic a...
Abstract:Molecular genetic studies of lung cancer have revealed that clinically evident lung cancers...
Lung cancer is a multistage process with poor prognosis and high morbidity. Importantly, the genetic...
BACKGROUND: Lung cancer is a multistage process with poor prognosis and high morbidity. Importantly,...
BACKGROUND:Lung cancer is a multistage process with poor prognosis and high morbidity. Importantly, ...
Lung cancer results from multiple changes in the genome of susceptible pulmonary cells caused by exp...
We report mapping of proteins of adenocarcinomas of the lung as a result of overexpression of the on...
Lung cancer is a leading cause of cancer morbidity. To improve an understanding of molecular causes ...
BACKGROUND: The transcriptional regulator c-Myc is the most frequently deregulated oncogene in human...
Background Lung cancer remains the world-wide leading cause of cancer morbidity and mortality as a ...
International audienceIn order to validate the use of the nude mouse as a model for studying lung ca...
Q1Q1The bioinformatic pipeline previously developed in our research laboratory is used to identify p...
Lung squamous cell carcinoma (SCC) is thought to arise from premalignant lesions in the airway epith...
BACKGROUND:Lung cancer is a leading cause of cancer morbidity. To improve an understanding of molecu...
Lung cancer has the highest mortality rate amongst all diagnosed malignancies with adenocarcinoma (A...
During the last decade, high-throughput technologies including genomic, epigenomic, transcriptomic a...
Abstract:Molecular genetic studies of lung cancer have revealed that clinically evident lung cancers...
Lung cancer is a multistage process with poor prognosis and high morbidity. Importantly, the genetic...
BACKGROUND: Lung cancer is a multistage process with poor prognosis and high morbidity. Importantly,...
BACKGROUND:Lung cancer is a multistage process with poor prognosis and high morbidity. Importantly, ...
Lung cancer results from multiple changes in the genome of susceptible pulmonary cells caused by exp...
We report mapping of proteins of adenocarcinomas of the lung as a result of overexpression of the on...
Lung cancer is a leading cause of cancer morbidity. To improve an understanding of molecular causes ...
BACKGROUND: The transcriptional regulator c-Myc is the most frequently deregulated oncogene in human...
Background Lung cancer remains the world-wide leading cause of cancer morbidity and mortality as a ...
International audienceIn order to validate the use of the nude mouse as a model for studying lung ca...
Q1Q1The bioinformatic pipeline previously developed in our research laboratory is used to identify p...
Lung squamous cell carcinoma (SCC) is thought to arise from premalignant lesions in the airway epith...
BACKGROUND:Lung cancer is a leading cause of cancer morbidity. To improve an understanding of molecu...
Lung cancer has the highest mortality rate amongst all diagnosed malignancies with adenocarcinoma (A...